Direct evidence of nonuniform distribution of vagal effects on dog atria.

The duration of the monophasic action potential (APD), the interval between atrial beats and the delay time between excitation of the right and left atria of dogs were measured, using coaxial suction electrodes, before and during vagal stimulation. The effect of vagal stimulation on the degree of shortening of APD varied at different recording sites in the atrium, the shortening being more pronounced in the right than in the left atrium. Threshold and rate of recovery after cessation of stimulation varied throughout the atrium. The results indicate that the vagal effect is nonuniformly distributed over the atrium. The time difference between excitation of the right and left atria increased with vagal stimulation under the present experimental condition, suggesting that a reduction of synchrony of excitation occurred in the atrial myocardial fibers as a whole. The same conclusion was derived from analysis of the pattern of the P wave before and during vagal stimulation. ADDITIONAL